You may need extra iron because of blood loss during kidney dialysis. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. May increase risk of hypotension. Where C= concentration of The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Your doctor will do laboratory tests to monitor your response. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Intravenous iron-dextran: therapeutic and experimental possibilities. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Applies only to oral form of both agents. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Med J Aust; 193(9):525-32. Recommended dosing and infusion rates for PI. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. To view formulary information first create a list of plans. Human studies not conducted. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. commonly, these are "preferred" (on formulary) brand drugs. This drug is available at the lowest co-pay. May increase risk of hypotension. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. https://www.uptodate.com/ (Requires subscription). Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Minor/Significance Unknown. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. The dosage of Venofer is expressed in mg of elemental iron. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. . Use Caution/Monitor. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Maximum recommended single dose: 300 mg (See Prescriber's Orders). The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Due Date form Ultrasound Report. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Volume of iron product required = 25 mL. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Applies only to oral form of both agents. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. This drug is available at a higher level co-pay. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Deferasirox chelates iron. This drug is available at a higher level co-pay. Monitor for signs and symptoms of hypotension following each administration of Venofer. Contraindicated. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. however iron sucrose requires multiple small intermittent doses over days to weeks. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. commonly, these are "non-preferred" brand drugs or specialty Applies only to oral form of both agents. *Repeat dose if iron deficiency anemia reoccurs. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. If we don't have the calculator you need we'll try to make it for you and add it to the website. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Share cases and questions with Physicians on Medscape consult. Applies only to oral form of both agents. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Use Caution/Monitor. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Canada residents can call a provincial poison control center. Separate dosing of tetracyclines from these products. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). If you have private insurance, Venofer or Monoferric may be on the list of covered medications. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. Diagnosis and management of iron deficiency anaemia: a clinical update. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Minor/Significance Unknown. Deferoxamine chelates iron. All Rights Reserved. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. May increase risk of hypotension. Applies only to oral form of both agents. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] 1 Dosing for patients who weigh less than 50 kg Contact the applicable plan The elemental iron product used is Iron sucrose 20 mg/mL. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Written by ASHP. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Last updated 28/06/2018 Enter values here and press 'Calculate'. There are physiological variation in iron reserves such as the decrease during menstruation period. Avoid or Use Alternate Drug. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Applies only to oral form of both agents. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Drug Des Devel Ther; 5: 5160. Ren Fail. 2012;2(4):288-335. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. For additional Safety Information, please see Full Prescribing Information. Kumpf VJ. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Human studies not conducted. Venofer treatment may be repeated if necessary. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Minor (1)iron sucrose, captopril. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Use Caution/Monitor. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. A: Generally acceptable. Use Caution/Monitor. . Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Your list will be saved and can be edited at any time. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Chandler G, Harchowel J, Macdougall I. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. Applies only to oral form of both agents. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Applies only to oral form of both agents. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. These can be input in g/dL, g/L or mmol/L. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Deferasirox chelates iron. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Applies only to oral form of both agents. Minor/Significance Unknown. 1996 Aug;11(4):139-46. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Most The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Interaction only with oral iron administration. MISSED DOSE: It is important to get each dose of this medication as scheduled. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. This document does not contain all possible drug interactions. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Use Caution/Monitor. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. . Step 2: Calculation and administration of the maximum individual iron dose(s): . It is unlikely . The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. If either is present, do not use the liquid. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Dosing Administration & Considerations . Minor/Significance Unknown. Either decreases levels of the other by inhibition of GI absorption. This information is not individual medical advice and does not substitute for the advice of your health care professional. Modify Therapy/Monitor Closely. 10th ed. Below the form there are further instructions on how to use the calculator. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Applies only to oral form of both agents. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Use Caution/Monitor. Applies only to oral form of both agents. Parenteral iron dextran therapy. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Individual plans may vary Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3]
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